2017

Dr David Deaton is the former Chief of Vascular and Endovascular surgery at Georgetown University Hospital and was most recently a staff vascular surgeon at the Cleveland Clinic.   Currently he is the chief medical officer at Syntactx, a clinical research organization, in New York in addition to a variety of consulting positions for start-up and established medical device firms. Dr Deaton has a long experience of vascular surgery and has been primarily involved in the development of several well-known medical devices, to include the first approved aortic endograft in the US (Ancure / Guidant) and, more recently, the Aptus EndoAnchor.  
 
Dr Deaton’s passion for innovation originates from the early 90’s when he became one of the few vascular surgeons involved in the pre-clinical development of the first bifurcated endograft introduced into clinical trials and he is a strong believer in interaction between surgeons and technical development. In this interview from the Veith Symposium in 2016, he explains his view on collaboration and development to improve treatment and patient outcome.

“I think that Endovab has very interesting technology that enables a variety of new treatment methods and opportunities for the aortic segment but also for other peripheral interventional techniques”, says Dr David Deaton.
 
David joins Endovab in the capacity of strategic clinical advisor and member of the board. “We are very happy to have Dr Deaton onboard with us, his experience, network, and insights to the American market are very valuable for us. This is particularly relevant now, as we are looking to expand the guidewire fixator technology to peripheral intervention, where the US is the dominating market.” Says Linus Bosaeus, CEO Endovab.

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Dr Liungman is presenting the first results from the LGF registry study for complex aortic repair at the Veith Symposium 2017. This includes experiences with the LGF from Chimney and Snorkel repair, as well as recent cases of arch aneurysm repair using pre-lined fenestrated grafts. 
 
See you in New York!
Saturday, November 18, 2017 at 11am in the Grand Ballroom East, 3rd Floor

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A technical paper describing a new method for f-EVAR has just been published in INNOVATION. The new method entails fixated guidewires and retrograde lining of the aortic branches, which eliminates the unpredictable searching of the branched vessels during fenestrated endovascular aortic repair. 
"This publication is an important step in spreading the knowledge and awareness of a new method to solve a well know challenge in fenestrated and branched aortic repair.” says Krister Liungman, Inventor of the Guidewire Fixator. 

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Endovab obtains further granted patent in Canada. The patent relate to a guidewire fixator, a new medical device that enables distal guidewire stability. Many endovascular procedures can benefit from a stable guidewire position, such as peripheral angioplasty as well as f-EVAR and Ch-EVAR.

 “This patent has been approved in several countries worldwide during the last year, and further acceptance is expected. This relates to one of our core technologies and we are pleased to see that the IP is growing as planned” comments Linus Bosaeus, CEO Endovab.

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The Endovab platform for distal guidewire fixation enables a new and patented drug delivery opportunity. By distal fixation of a micro catheter, a drug could be delivered from an external pump directly to a target site while the patient is active, without catheter displacement.
 
Intra-arterial drug delivery is known to allow for higher local drug concentration while reducing side effects compared to systemic delivery. Targeted drug delivery also allows the use of the primary non-metabolized synthesis, prior to first passage metabolism in the liver or systemically.
 
Do you have a drug that needs targeted delivery?
 
For further information about our drug delivery concept and IP, please contact us at info.endovab.com. 

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Endovab has recently had another patent relating to the Liungman Guidewire Fixator (LGF) technology accepted in France, Germany, Great Britain and Italy. The patent relates the mechanism that allows ‘over the wire’ delivery and retrieval.
 
“The ability to delivery and particularly retrieve an over-the-wire device requires a flexible and reliable delivery system. Our solutions is uniquely simplistic and easy to use, while at the same time providing accurate and reliably functionality.” Comments Krister Liungman, Founder of Endovab and inventor of the LGF.

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When using pre-lined branched guidewires, there is always a risk for wire entanglement. We propose using multi lumen catheters to obtain parallel wires and this video demonstrates the method we propose to sort out and prevent entanglement when using three guidewires, for example for a pre-lined pararenal case as shown.
 
We believe using a three-lumen catheter works great and offers a very rapid and intuitive sorting step.
 
Are you familiar with any existing multi lumen catheter or sheath that can hold three 0,035” guidewires and be suitable for this manoeuvre? info@endovab.com

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The LGF is now being part of a chimney registry study managed by Jean-Paul De Vries at St. Antonius Hospital Nieuwegein in the Netherlands. As part of a larger registry for chimney procedures, the LGF is used to facilitate a stable guidewire position for the chimney grafts throughout the procedure. A stable position supports delivery and positioning of the chimney graft or grafts, as well as securing the position while deploying and expanding multiple grafts simultaneously.



“The LGF is quite an interesting tool that has the potential to improve and simplify chimney procedures, and to reduce guidewire manipulations in the visceral arteries. We are happy to be the first team to work on this indication together with Endovab” says Jean-Paul de Vries, Head of Vascular Sugery at St. Antonius Hospital Nieuwegein.

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Endovab has been granted a new European patent that will be issued on the 5th of April. The patent relates to technology for delivering and retrieving a medical device inside the body. The flexible mechanism has been designed to allow delivery and retrieval in tortuous anatomies and is currently utilised in the Liungman Guidewire Fixator. 

You will find more information on Endovab IP here

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Unstable guidewire position during chimneys and snorkel procedures is an imminent risk that requires experience and attention. Professor Mario Lachat at the University of Zürich is one of the international pioneers of parallel graft and sandwich techniques using chimneys and snorkels to both visceral and arch branches.
 
As a scientific board member, Mario Lachat was the first to use the LGF in a snorkel case in March 2017 as a pilot for a planned study. The LGF was used to secure the guidewire position in the right renal artery while deploying three Viabahn stentgraft that were then reinforced with bare Wallstents. The entire procedure entailed a full metal jacket stentgraft treatment, including parallel grafts with snorkels connecting the renal arteries and a chimney for the superior mesenteric artery. 
 
The procedure was successfully completed and the LGF performed as intended.
 
“I liked the device, it’s a great tool” – Mario Lachat.
 
If you are interested to learn more about the chimney and snorkel technique using the LGF, or if you want to sign up interest for early adoption and study participation, please contact Dr Krister Liungman, Krister.liungman@endovab.com.

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The facilitated method for f-EVAR using the LGF has been developed to make the procedure stepwise and predictable. By catheterisation of the branch vessels prior to insertion of the main stentgraft, the connection of the target vessels and the fenestrated graft is made on the table prior to introducing the stentgraft. This video describes the steps in the procedure illustrated in a pig model.

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Our clinical lead Dr Krister Liungman presented the Liungman Guidewire Fixator at LINC this Thursday. It was a busy week for all participants and the LINC event attracted a seamless mix of clinicians and industry, over 5000 participants! Radiation awareness was a hot topic and it seems like the industry is also aiming to reduce procedure duration by offering pre-loaded catheters and through-and-through wires. If you like to know more about what Dr Liungman presented, don’t hesitate to contact us at info@endovab.com

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Results from the LGF clinical study and more will be presented at the LINC conference, in the Innovation Forum, Thursday 26th at 12:54 in room 7. If you want to know more, please email us at info@endovab.com and we will send you a copy of the clinical report internal paper. 

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